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Frailty represents an important challenge for aging populations. As a concept it is full of 'known unknowns' such as which mechanisms lead to frailty and how it is best managed. In order to examine these circumstances, the new science of understanding and managing frailty requires an appropriate framing of the problem. [lire la suite]
Aging is a major risk factor for chronic diseases, which in turn can provide information about the aging of a biological system.
This publication serves as an introduction to systems biology and its application to biological aging. Key pathways and processes that impinge on aging are reviewed, and how they contribute to health and disease during aging is discussed. [lire la suite]
Outlining the complex interaction between the two phenomena
Cancer is clearly an age-related disease. Recent research in both aging and cancer has demonstrated the complex interaction between the two phenomena. This affects a wide spectrum of research and practice, anywhere from basic research to health care organization. [lire la suite]