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Drug metabolism is the enzymatic conversion of one chemical compound into another, ultimately resulting in a product that can be excreted by the kidneys. In the processes by which the body excretes drugs into fluids such as urine or bile, metabolism is an essential step in converting drugs into more water-soluble compounds by increasing their polarity. [lire la suite]
In 1993, the Diabetes Control Complications Trial (DCCT) study established that chronic hyperglycemia initiates and progresses to microvascular complications such as retinopathy in type 1 diabetes mellitus (T1DM).
The milestone message from DCCT has been that early near-normalization of blood glucose in recent-onset T1DM with glycated hemoglobin (HbA1C) <7. [lire la suite]
Aging is a major risk factor for chronic diseases, which in turn can provide information about the aging of a biological system.
This publication serves as an introduction to systems biology and its application to biological aging. Key pathways and processes that impinge on aging are reviewed, and how they contribute to health and disease during aging is discussed. [lire la suite]
Recent advances and surgical pearlsOver the last two decades, tremendous progress has been made in vitrectomy surgery, most importantly the significant reduction of the gauge and implementation of microincision vitrectomy surgery (MIVS). [lire la suite]
Inflammatory Bowel Disease (IBD) is a chronic debilitating disorder that occurs at any age and in populations around the world. Its pathogenesis is believed to involve a combination of genetic susceptibility, immune and external environmental factors, including the gut microbiota. [lire la suite]
Orbital surgery deals with a variety of complications occurring in the eye socket comprising inflammatory diseases like thyroid-associated orbitopathy, tumors, infections, and injuries from trauma that affect eye function.
In this volume, renowned European orbital surgery experts share their professional experience and expertise. [lire la suite]
The body of knowledge in most medical specialties is rapidly expanding, making it virtually impossible to follow all advances in clinical and basic sciences that are relevant to a given field. This is particularly true in pediatric endocrinology, at the cross-road of pediatrics, endocrinology, development and genetics. [lire la suite]
State of the art of diagnosis and treatment of pediatric thyroid diseases
This book presents a comprehensive overview of pediatric thyroid diseases and thus provides a useful tool for clinical problem solving. Opinion leaders in the field present reviews on all relevant diseases of the hypothalamic-pituitary-thyroid axis. [lire la suite]
Recent progress in defining the genetic basis for type 2 diabetes
Over the past decade, there has been unprecedented progress in our understanding of the genetic basis of type 2 diabetes driven largely by technological advances which have facilitated genome-wide studies. [lire la suite]
Presenting current knowledge regarding the relationship between exercise and diabetes, this publication discusses in detail the physiologic, molecular and genetic mechanisms involved in this interaction. [lire la suite]
Erosive tooth wear is a multifactorial condition of growing concern to the clinician and the subject of extensive research. Since the publication of the first edition of the book with the title Dental Erosion, new knowledge for a better understanding of this important subject has been gathered. [lire la suite]
The development of one of the most intriguing conditions in medicine
Hysteria is probably the condition which best illustrates the tight connection between neurology and psychiatry. While it has been known since antiquity, its renewed studies during the 19th century were mainly due to the work of Jean-Martin Charcot and his school in Paris. [lire la suite]
The multimodality management of strategies of mild traumatic brain injury and concussion
The increasing recognition of concussion and its associated consequences has focused international attention on mild traumatic brain injury. The need for early diagnosis, evaluation, and management has expanded dramatically. [lire la suite]
Unlike adult gastroenterology, pediatric gastroenterology is characterized by developmental disorders; the approach to the same disease condition may therefore be widely different, and there is an increasing need from pediatric gastroenterologists and pediatricians for easy diagnostic tools. [lire la suite]
The UN Millennium Development Goals (MDG) in nutrition are at the core of this book, with special attention to young women and their children. The first part is dedicated to the overall analysis of the world nutrition situation as related to achieving the MDG. [lire la suite]
A noninvasive, reliable and patient-friendly diagnostic technique
Because of its many advantages optical coherence tomography (OCT) has revolutionized the way in which retinal diseases are screened and managed and how treatments are monitored. In this volume the latest developments and findings are presented by experts in their respective fields. [lire la suite]
Today, nearly 60 years after the invention of the first medical laser, multiple laser and light systems exist and are applied in various medical specialties such as dermatology, ophthalmology, and urology. This volume - the first in the series Aesthetic Dermatology - focuses on the laser treatment of cutaneous lesions with a vascular target. [lire la suite]
The relation between nutrition and growth in children is one of the key concerns of pediatric health that touches a multitude of specialties. Exchanging concepts and knowledge between professionals of all the different disciplines involved is thus crucial to facilitate research and interdisciplinary clinical collaborations. [lire la suite]
Advances in basic and clinical research, diagnostics and management
Human papillomavirus (HPV) infection transcends multiple fields of science and medicine. The management of HPV-related disease is demanding and often requires a persistent multimodal approach involving various medical disciplines. [lire la suite]
Child maltreatment represents one of the most adverse and stressful challenges that confront children.
As the maltreating home is a dramatic violation of environments believed to promote adaptive and healthy development, research on child maltreatment informs developmental theory by elucidating the conditions necessary for normal emotional development. [lire la suite]
The latest knowledge of TIA as a medical emergency
Transient ischemic attack (TIA) is well known to be a prodromal syndrome of ischemic stroke. However, TIA is easily neglected or underestimated by patients or even general physicians because the symptoms naturally disappear without treatment. Despite this, early after the onset of TIA the patients are at very high risk of stroke. [lire la suite]
Remarkable progress in the development of new concepts and techniques used in reconstructive surgery of microtia/atresia of the external auditory canal (EAC) has been made since the beginning of the 21st century. [lire la suite]
Our daily food intake not only provides the calories and the macro- and micronutrients necessary for survival - nutrients also have a tremendous potential to modulate the actions of the immune system, a fact which has a significant impact on public health and clinical practice. [lire la suite]
Indocyanine green (ICG) fluorescence has been used for imaging purposes for more than half a century; First employed by ophthalmologists for visualizing the retinal artery in the late 1960s, the application of ICG fluorescence imaging has since been continuously expanded. [lire la suite]
The discovery of proton pump inhibitors (PPIs) and their development over the years has dramatically changed the management of acid-related diseases. Today, the therapeutic domain of PPIs ranges from relief of symptoms to cure of mucosal lesions in the upper gastrointestinal tract. PPIs are among the most widely sold drugs in the world and are now even available as over-the-counter medication. [lire la suite]
This is a work of advocacy, whose prime objective is to inform people about the relationship between nutrition security and public health. It draws on the thinking and experience of a selected number of experts in the field of nutrition and public health. [lire la suite]
A topical and comprehensive description of current developments in the pharmacological treatment of anxiety disorders
Anxiety disorders are not uncommon and are often ?comorbid' with other forms of mental disorders. This publication provides an update on the origins and the causes of anxiety disorders and their related symptoms. [lire la suite]
Recognition of evidence-based medicine is not only increasing rapidly, but it has become essentiel to pediatric nutrition.
Starting with some methodological issues - discussing systemic reviews, meta-analyses and clinicat trials - this publication then concisely summarizes current knowledge as well as ignorance and uncertainty regarding selected aspects of childhood nutrition. [lire la suite]