Hormone Resistance and Hypersensitivity
From Genetics to Clinical Management.
Providing an overview of the most recent advances and breakthrough developmentsOver recent years, impressive advances in genetic/epigenetic technology have greatly improved the understanding of the pathogenesis of pediatric endocrine diseases due to hormone resistance and hypersensitivity.This book presents reviews of thyroid hormone and thyroid hormone receptor [...]
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Auteur : M. MAGHNIE , S.LOCHE , M. CAPPA , L. GHIZZONI , R. LORINI
Editeur : Karger
Collection : Endocrine Development - 24
Date parution : 02/2013Bilingue : Français | Anglais
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Providing an overview of the most recent advances and breakthrough developments
Over recent years, impressive advances in genetic/epigenetic technology have greatly improved the understanding of the pathogenesis of pediatric endocrine diseases due to hormone resistance and hypersensitivity.
This book presents reviews of thyroid hormone and thyroid hormone receptor resistance, and genetics and epigenetics of parathyroid hormone resistance. Abnormalities of the pituitary-gonadal axis affecting puberty as well as androgen receptor are covered. Novel insights into the diseases affecting ACTH, glucocorticoid and aldosterone receptors are discussed. Further chapters address new aspects of the physiology of the GH and IGF-1 axis as well as the diseases related to GH-IGF-1 receptor and post-receptor signaling defects. A key chapter on metabolic insights into insulin resistance is also included.
Covering clinical and genetic aspects of hormone resistance and hypersensitivity, this book will be a useful tool in the hands of scientists, physicians and other healthcare professionals who wish to be up to date with novel research findings in this area.
Sommaire et contenu du livre "Hormone Resistance and Hypersensitivity - From Genetics to Clinical Management."
ContentsVII Preface
Maghnie, M. (Genoa); Loche, 5. (Cagliari); Cappa, M (Rome); Ghizzoni, L. (Turin); Lorini, R (Genoa)
1 Thyroid Hormone Transporters and Resistance
Visser, T.J (Rotterdam)
11 Genetics and Epigenetics of Parathyroid Hormone Resistance
Bastepe, M. (Boston, Mass.)
25 Gonadotropin Resistance
Latronico, AC; Arnhold, LJP (5ào Paulo)
33 Clinical and Molecular Aspects of Androgen Insensitivity
Hiort, 0. (Lübeck)
41 Exploring the Molecular Mechanisms of Glucocorticoid Receptor Action from Sensitivity to Resistance
Ramamoorthy, 5.; Cidlowski, JA (Research Triangle Park, N.C)
57 ACTH Resistance: Genes and Mechanisms
Meimaridou, E.; Hughes, CR; Kowalczyk, J; Chan, L.F.; Clark, AJL.; Metherell, LA (London)
67 Primary Generalized Familial and Sporadic Glucocorticoid Resistance
(Chrousos Syndrome) and Hypersensitivity
Charmandari, E. (Athens/Bethesda, Md.); Kino, T. (Bethesda, Md.); Chrousos, G.P. (Athens/Bethesda, Md.)
86 Pseudohypoaldosteronism
Riepe, F.G. (Kiel)
96 New Aspects of the Physiology of the GH-IGF-l Axis
Vottero, A (Parma); Guzzetti, C; Loche, 5. (Cagliari)
106 Molecular and Clinical Aspects of GHRH Receptor Mutations
Corazzini, V; 5alvatori, R (Baltimore, Md.)
118 Current Issues on Molecular Diagnosis of GH Signaling Defects
Feigerlova, E.; Hwa, v.; Derr, MA; Rosenfeld, RG. (Portland, Oreg.)
128 Molecular IGF-l and IGF-l Receptor Defects: From Genetics to Clinical Management
Walenkamp, M.JE. (Amsterdam); Losekoot, M.; Wit, JM. (Leiden)
138 Phenotypes, Investigation and Treatment of Primary IGF-l Deficiency
Savage, M.O. (London)
150 Human Congenital Perilipin Deficiency and Insulin Resistance
Kozusko, K.; Pate l, S.; Savage, DB. (Cambridge)
156 Author Index 157 Subject Index
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