Nous utilisons des cookies pour vous proposer des contenus et services adaptés. En poursuivant votre navigation sur ce site, vous acceptez l'utilisation de cookies.
Ce site respecte la loi RGPD du 25 mai 2018. Pour en savoir plus, cliquez ici
(+33) 02 47 61 20 22 Du lundi au vendredi de 10H à 16H30

pH of the Skin: Issues and Challenges

pH of the Skin: Issues and Challenges - karger  - 9783318063844 -
pH of the Skin: Issues and Challenges 

Auteur : 

Editeur : KARGER

Collection : Currents Problems in Dermatology - 54

Langue : Anglais

Date parution :

Ninety years ago - in 1928, the term acid mantle was coined by the physicians Heinrich Schade and Alfred Marchionini in Kiel, Germany. A decade later Marchionini and several coworkers published 5 scientific communications in the Klinische Wochenschrift on ??oeDer Säuremantel der Haut und Bakterienabwehr” (acid mantle and defense against bacteria). They described experimental detail, documented age- and body site as well as skin disease-dependent skin pH shifts, and discussed the significance of the pH and bacterial growth on the skin. In their fourth and fifth communication, they made the first connection between the altered quantitative and qualitative bacterial growth in pathologically modified skin and the shifted skin pH and attributed it partly to the gap in the acid mantle (pathologische Lücke des Säuremantels). They also investigated the pH of several topical dermatologic preparations and concluded that their benefit can at least partly be attributed to their acid character and recommended the systematic investigation of acid treatments in dermatology. At that time, the physiologic role of the acid skin surface was thought to be a protective mechanism against invading organisms. Hence, it seemed reasonable to allocate protection to an easy and conceivable term such as ??oemantle.” Today, ??oeacid mantle” as a term is still a very suitable metaphor to illustrate the protective quality of the ??oeacid” in the skin and the term has become part of colloquial speech. In the meantime, our understanding of the skin pH has broadened, and we know that the acid character and its gradual change within the skin also help to orchestrate epidermal differentiation and corneocyte shedding. For many more biochemical processes within the skin, the compartmental pH is crucial, for example, in pigmentation, ion homeostasis, epidermal (stem) cell behavior, and so on. The often existing difference between the H+ concentration of extra- and intracellular as well as subcellular compartments establishes an ionic, electric, and/or osmotic driving force; hence, H concentration per se acts as an extra-, intra,- and subcellular signaling modality affecting and controlling many cellular functions. One may even consider pH a universal signal and effector. It is therefore also no surprise that skin pH shifts have been observed in various skin pathologies. More recently, in carefully controlled trials (acne, atopic dermatitis, incontinence-associated dermatitis, aged skin), the benefits of targeted skin acidification have become evident and the use of topical preparations with reduced pH may be recommended. The currently prevailing formulation concepts for direct acidification are based on a reduced pH of the hydrophilic product phase in combination with a buffer with a sufficiently high buffering capacity within the vehicle.


En suivant ce lien, retrouvez tous les livres dans la spécialité Dermatologie.
Reliure : Relié
ISBN 10 : 3318063843
ISBN 13 : 9783318063844
185,00 €
En stock , expédition à 0.01€ aujourd'hui (en savoir plus)

Avis clients sur pH of the Skin: Issues and Challenges - karger - Currents Problems in Dermatology

(Ils sont modérés par nos soins et rédigés par des clients ayant acheté l'ouvrage)
Donnez votre avis
Dernières parutions dans Currents Problems in Dermatology, Adverse Reactions to Biologics
130,00 €
Dernières parutions dans Currents Problems in Dermatology, Diagnosis and Therapy of Tattoo Complications
157,00 €
Dernières parutions dans Currents Problems in Dermatology, Itch - Management in Clinical Practice
177,00 €
Dernières parutions dans Currents Problems in Dermatology, Perspiration Research
149,00 €
Dernières parutions dans Currents Problems in Dermatology, Skin Barrier Function
167,00 €
Dernières parutions dans Currents Problems in Dermatology, Tattooed Skin and Health
199,00 €
Dernières parutions dans Currents Problems in Dermatology, Alopecias
186,00 €
Dernières parutions dans Currents Problems in Dermatology, Actinic Keratosis
166,00 €
Dernières parutions dans Currents Problems in Dermatology, Human Papillomavirus
186,00 €
Dernières parutions dans Currents Problems in Dermatology, Dermatological Diseases and Cumulative Life Course Impairment
165,00 €
Dernières parutions sur Dermatologie, Progrès en Dermato-Allergologie. Gerda 2020
64,00 €
Dernières parutions sur Dermatologie, Pas de visuel pour
39,90 €
Dernières parutions sur Dermatologie,
23,50 €
Dernières parutions sur Dermatologie, Dermatologie esthétique
119,00 €
Dernières parutions sur Dermatologie, Ordonnances en dermatologie 2020
35,00 €
Dernières parutions sur Dermatologie, Advanced Cutaneous Squamous Cell Carcinoma
7,00 €
Dernières parutions sur Dermatologie, Le petit dermato illustré
15,00 €
Dernières parutions sur Dermatologie, La télédermatologie en pratique libérale
39,00 €
Dernières parutions sur Dermatologie, Progrès en dermato-allergologie
64,00 €
Dernières parutions sur Dermatologie, Varices et télangiectasies des membres inférieurs
35,00 €
Dernières parutions sur Dermatologie, Cutaneous T-cell Lymphoma
18,00 €
Dernières parutions sur Dermatologie, Dermatologie de l'enfant
95,00 €
Dernières parutions sur Dermatologie, Dermatologie
28,00 €
Dernières parutions sur Dermatologie, Ordonnances en dermatologie
35,00 €
Dernières parutions sur Dermatologie, Guide pratique de la maladie veineuse thromboembolique
15,00 €
Dernières parutions sur Dermatologie, Guérir du psoriasis
19,95 €
Dernières parutions sur Dermatologie, 50 dessins pour raconter la dermatite atopique
16,00 €
Dernières parutions sur Dermatologie, Progrès en dermato-allergologie : Dijon 2018
64,00 €

Rubriques associées pour pH of the Skin: Issues and Challenges :