Cancer and Aging
From Bench to Clinics
Outlining the complex interaction between the two phenomenaCancer is clearly an age-related disease. Recent research in both aging and cancer has demonstrated the complex interaction between the two phenomena. This affects a wide spectrum of research and practice, anywhere from basic research to health care organization.Core examples of these close [...]
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Auteur : M. EXTERMANN
Editeur : Karger
Collection : Interdiscinary Topics in Gerontology - 38
Date parution : 01/2013Bilingue : Français | Anglais
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Outlining the complex interaction between the two phenomena
Cancer is clearly an age-related disease. Recent research in both aging and cancer has demonstrated the complex interaction between the two phenomena. This affects a wide spectrum of research and practice, anywhere from basic research to health care organization.
Core examples of these close associations are addressed in this book. Starting with basic research, the first chapters cover cancer development, mTOR inhibition, senescent cells altering the tumor microenvironment, and immune senescence affecting cancer vaccine response. Taking into account the multidisciplinarity of geriatric oncology, several chapters focus on geriatric and oncologic aspects in patient assessment, treatment options, nursing and exercise programs. The book is rounded off by a discussion on the impact of the metabolic syndrome illustrating the interactions between comorbidity and cancer and a chapter on frailty.
This book provides the reader with insights that will hopefully foster his or her reflection in their own research and practice to further the development of this most exciting field. Given the aging of the population worldwide and the high prevalence of cancer, it is essential reading not only for oncologists and geriatricians but for all health practitioners.
VIII + 170 p., 8 fig., 2 in color, 13 tab., hard cover, 2013
Sommaire et contenu du livre "Cancer and Aging - From Bench to Clinics"
ContentsVII Preface
Extermann, M. (Tampa, Fla)
1 Chronic Mechanistic Target of Rapamycin Inhibition: Preventing Cancer to Delay Aging, or Vice Versa?
Sharp, ZD.; Curiel, U; Livi, CB. (San Antonio, Tex.)
17 Senescent CeUs and Their Secretory Phenotype as Targets for Cancer Therapy
Velarde, MC; Demaria, M. (Novato, Cal if); Campisi, J (Novato, Calif/Berkeley, Calif)
28 Cancer Vaccination at Older Age
Gravekamp, C (Bronx, NY)
38 Immunology of Aging and Cancer Development
Fulop, T (Sherbrooke); Larbi, A (Singapore); Kotb, R (Sherbrooke);
Pawelec, G. (Tuebingen)
49 Metabolie Syndrome and Cancer: From Bedside to Bench and Back
Extermann, M. (Tampa, Fla)
61 Frailty: A Common Pathway in Aging and Cancer
t'laoucc l. am9a, ra~ 73 Targeting Age-Reated Changes in the Bioogy of Acute Myeoid leukemia: Is the Patient Seeing the Progress?
Vey, N. (Marseille)
85 Comprehensive Geriatrie Assessment in Oncology
Mohile, S.G.; Magnuson, A (Rochester, NY)
104 Pharmacology of Aging and Cancer: How Useful Are Pharmacokinetie Tests?
Lichtman, SM (Commack, N.YJNewYork, NY)
124 Surgery in Older Cancer Patients -Recent Results and New Techniques:
Worth the Investment?
van Leeuwen, B1.; Huisman, M.G. (Groningen); Audisio, RA (St. Helens)
132 Organizing the Geriatrician/Oncologist Partnership: One Size Fits Ali?
Practical Solutions
Holmes, H.M. (Houston, Tex.); Albrand, G. (Francheville)
139 Geriatrie Oncology Nursing: Beyond Standard Care
Overcash, J (Columbus, Ohio)
146 Exercise for Older Cancer Patients: Feasible and Helpful?
Klepin, H.D. (Winston-Salem, N.C); Mohile, S.G. (Rochester, NY); Mihalko, S (Winston-Salem, l'Je)
158 Aging and Cancer -Addressing a Nation's Challenge
Bréchot, J-M.; Le Quellec-Nathan, M.; Buzyn, A. (Boulogne-Billancourt)
165 Author Index 166 Subject Index
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